struct rte_vdpa_device *vdev = rte_vhost_get_vdpa_device(vid);
        struct mlx5_vdpa_priv *priv =
                mlx5_vdpa_find_priv_resource_by_vdev(vdev);
+       int ret;
 
        if (priv == NULL) {
                DRV_LOG(ERR, "Invalid vDPA device: %s.", vdev->device->name);
                DRV_LOG(ERR, "Too big vring id: %d.", vring);
                return -E2BIG;
        }
-       return mlx5_vdpa_virtq_enable(priv, vring, state);
+       pthread_mutex_lock(&priv->vq_config_lock);
+       ret = mlx5_vdpa_virtq_enable(priv, vring, state);
+       pthread_mutex_unlock(&priv->vq_config_lock);
+       return ret;
 }
 
 static int
        }
        mlx5_vdpa_config_get(pci_dev->device.devargs, priv);
        SLIST_INIT(&priv->mr_list);
+       pthread_mutex_init(&priv->vq_config_lock, NULL);
        pthread_mutex_lock(&priv_list_lock);
        TAILQ_INSERT_TAIL(&priv_list, priv, next);
        pthread_mutex_unlock(&priv_list_lock);
                        priv->var = NULL;
                }
                mlx5_glue->close_device(priv->ctx);
+               pthread_mutex_destroy(&priv->vq_config_lock);
                rte_free(priv);
        }
        return 0;
 
                                                                 priv->event_us;
        while (1) {
                max = 0;
+               pthread_mutex_lock(&priv->vq_config_lock);
                for (i = 0; i < priv->nr_virtqs; i++) {
                        cq = &priv->virtqs[i].eqp.cq;
                        if (cq->cq && !cq->armed) {
                                DRV_LOG(DEBUG, "Device %s traffic was stopped.",
                                        priv->vdev->device->name);
                                mlx5_vdpa_arm_all_cqs(priv);
+                               pthread_mutex_unlock(&priv->vq_config_lock);
                                pthread_mutex_lock(&priv->timer_lock);
                                priv->timer_on = 0;
                                while (!priv->timer_on)
                } else {
                        priv->last_traffic_tic = current_tic;
                }
+               pthread_mutex_unlock(&priv->vq_config_lock);
                mlx5_vdpa_timer_sleep(priv, max);
        }
        return NULL;
                uint8_t buf[sizeof(struct mlx5dv_devx_async_event_hdr) + 128];
        } out;
 
+       pthread_mutex_lock(&priv->vq_config_lock);
        while (mlx5_glue->devx_get_event(priv->eventc, &out.event_resp,
                                         sizeof(out.buf)) >=
                                       (ssize_t)sizeof(out.event_resp.cookie)) {
                struct mlx5_vdpa_virtq *virtq = container_of(eqp,
                                                   struct mlx5_vdpa_virtq, eqp);
 
+               if (!virtq->enable)
+                       continue;
                mlx5_vdpa_cq_poll(cq);
                /* Notify guest for descs consuming. */
                if (cq->callfd != -1)
                        eventfd_write(cq->callfd, (eventfd_t)1);
                if (priv->event_mode == MLX5_VDPA_EVENT_MODE_ONLY_INTERRUPT) {
                        mlx5_vdpa_cq_arm(priv, cq);
+                       pthread_mutex_unlock(&priv->vq_config_lock);
                        return;
                }
                /* Don't arm again - timer will take control. */
                pthread_cond_signal(&priv->timer_cond);
        }
        pthread_mutex_unlock(&priv->timer_lock);
+       pthread_mutex_unlock(&priv->vq_config_lock);
 }
 
 int